Advanced Cellular Repair


Cytokines help with immune cell communication. The maintenance of health requires a delicate balance. When out of balance, chronic disease can occur. The use of cytokines offers hope for patients suffering from chronic diseases, including osteoarthritis and degenerative disc disease. Cytokines positively affect the local-environments of the cells by helping to organize cellular tasks. These molecules provide repair instructions at the cellular level, this creates a change in the metabolism of pathways that extend from the cells to the tissues. Various combinations of cytokines can be inflammatory or anti-inflammatory and signal the combination of certain combinations of these biomolecules help to rebuild damaged tissues.

Addison Pain & Regenerative Medicine through the Boca Raton Institute of Regenerative Medicine network has made cytokine therapy available for our patients with FDA-registered oral cytokines. Much of the research in oral cytokine therapy has been done by Dr. Jo Serrentino. Oral cytokine therapy is created proprietary nano-technology and does not function like a supplement as it works directly in the extracellular matrix where cell signaling occurs. This form of treatment can provide the components necessary to the rebuilding of the connective tissue and musculoskeletal injuries and is a useful adjunct for regenerative treatments, such as, platelet rich plasma (PRP) and stem cell therapy.

The term “anti-aging” can have a number of different meanings. There are many clinics and healthcare providers who use this term to mean identifying and correcting hormonal imbalances. While this is part of the solution to the problem, it does not address other key elements that are involved in regulating the aging process.

Nicotinamide adenine dinucleotide (NAD) is a co-enzyme found in all living cells that is essential in helping to form ATP, which is the energy molecule for the body. We lose up to 40-50% of our NAD between the ages of 40-60. NAD effects the mitochondria, which is the powerhouse of the cell. Deficient NAD is thought to be involved with the decline of mitochondria function. NAD is thought to be involved in activation of the Sirtuin genes, which are also turned on by exercise and starvation. Sirtuin gene expression produces sirtuin (SIRT)- proteins, which are involved in controlling mitochondria health and function. Increased levels of NAD is associated with higher Sirtuin gene functioning. SIRT-1 is associated with the formation of new mitochondria. SIRT-3 is associated with keeping the mitochondria running smoothly. NAD requires a form of vitamin B3, which is nicotinamide riboside (NR) and pterostilbene. This combination is available as an oral formula made by Elysium.

NO (nitrous oxide) is one of the smallest signaling molecules in the body. NO can act as a stimulator or stem cell proliferation and has a critical role in pain relief, dilation of blood vessels, and modulating our immune system.

There are three main forms of NO in the body - NOS-1 or neuronal, NOS-2 or inducibile (iNOS), and NOS-3 or endothelial (eNOS). iNOS is of concern as it is associated with inflammation as an inflammatory mediator, but is essential for killing certain bacteria, regulating T cell proliferation and differentiation and regulating leukocyte recruitment. Macrophages are involved in the production of NO and is associated with the production of M1 or inflammatory macrophages. NO in the bone marrow is made by the bone marrow stromal cells. eNOS is the form of NO in bone marrow. As we age, the amount of NO produced declines.

Neo-40 made by Humann is an excellent source for oral nitrous oxide supplementation.